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Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in CA_(1) sector in rats

Xu Changqing, Zhang Zongming, Xia Zuoli, Wu Caihong, Zhou Peiai

Department of Neurology,Central Hospital of Jiangmen District.Jiangmen 529071,Guangdong；China；Department of Gerontology,Affiliated Hospital,Taishan Medical College.Tai^an 271000,Shandong

Abstract

The effects of glutamate on the transient outward potassium current of dissociated hippocampal CA_(1) neurons of 7-10d rats were studied by the whole-cell patch clamp technique. It was found that glutamate could block the transient potassium current in a dose- and time-dependent manner. The effect was partly voltage-dependent. These results suggest that glutamate may decrease the membrane conductance of K~(+) channels in hippocampal neurons.

Key words: Glutamate;Hippocampus;Neurons;Electrophysiology

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Citing This Article：

Xu Changqing, Zhang Zongming, Xia Zuoli, Wu Caihong, Zhou Peiai. Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in CA_(1) sector in rats. Acta Physiol Sin 1999; 51 (1): 55-59 (in Chinese with English abstract).