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Effect of ACTH on the expression of somatostatin and c-fos in the spinal cord and formalin evoked pain response

Wu Qiang, Li Xicheng, Ruan Huaizhen, Li Haidi

Department of Physiology,Third Military Medical University.Chongqing 400038

Abstract

Subcutaneous injection of formalin in the right hindpaw increased c-fos-like immunoreactivity (FLI), somatostatin-like immunoreactivity (Som-LI), Som-LI/FLI and perprosomatostatin mRNA (PPS-mRNA) in neurones of right spinal dorsal horn and significantly enhanced pain intensity rating. ACTH decreased the FLI, Som-LI, Som-LI/FLI and PPS-mRNA levels of the spinal cord evoked by formalin. The decrease of c-fos or Som level due to intrathecal injection of ACTH in rats with chronic pain was prevented by injection of cyproheptadine, but not by bicuculline and naloxone.

Key words: ACTH;Somatostatin;Proto oncogene c-fos;Spinal cord;Immunohistochemistry;In situ hybridization

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Citing This Article：

Wu Qiang, Li Xicheng, Ruan Huaizhen, Li Haidi. Effect of ACTH on the expression of somatostatin and c-fos in the spinal cord and formalin evoked pain response. Acta Physiol Sin 1999; 51 (1): 60-64 (in Chinese with English abstract).