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TRPM2: a multifunctional ion channel for oxidative stress sensing

Xiaochen Ru^*, Xiaoqiang Yao

Shenzhen Research Institute and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China

Abstract

Transient receptor potential (TRP) superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1–8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca2+-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose (ADPR), Ca2+, H2O2 and other reactive oxygen species (ROS). It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca2+]i increase and contributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic target for oxidative stress-related diseases. This review will highlight recent progress in this field.

Key words: TRPM2; oxidative stress; Ca2+ signaling; cardiovascular diseases; inflammation

Received: 　　Accepted:

Corresponding author: 茹筱晨　　E-mail: ruxiaochen2013@gmail.com

Citing This Article：

Xiaochen Ru, Xiaoqiang Yao. TRPM2: a multifunctional ion channel for oxidative stress sensing. Acta Physiol Sin 2014; 66 (1): 7-15 (in Chinese with English abstract).