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Naloxone and electroacunpunture (EA) improve the immune function of traumatized rats

Du Lina, Jiang Jianwei, Wu Gencheng, Cao Xiaoding

State Key Laboratory of Medical Neurobiology,Shanghai Medical University.Shanghai 200032

Abstract

The present study was undertaken to examine the effects of intracerebroventricular (icv) injection of naloxone (an antagonist of opioid receptors) and electroacupuncture (EA) on the natural killer (NK) cell activity, lymphocyte proliferation and induction of interleukin-2 (IL-2) production of spleen lymphocytes of surgically traumatized rats. The NK cell activity, the spleen lymphocyte proliferation and the induction of IL-2 production were all significantly inhibited following traumatization. Compared to the traumatic were antagonised by icv injection of naloxone.

Key words: Naloxone;Trauma;Electroacupuncture (EA);Natural killer cell activity lymphocyte;Proliferation interleukin-2;

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Citing This Article：

Du Lina, Jiang Jianwei, Wu Gencheng, Cao Xiaoding. Naloxone and electroacunpunture (EA) improve the immune function of traumatized rats. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).