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RAPID inhibitory effect of glucocorticoids on ACh-induced current in rat phaeochromocytoma cells

Shi Lijun, Wang Chunan, Chen Yizhang

Department of Physiology,Department of Basic Medicine,Second Military Medical University.Shanghai 200043

Abstract

A rapid effect of glucocorticoids (GC) on acetycholine-induced current in rat phaeochromocytoma (PC12) cells and its possible mechanism were investigated by whole-cell clamp technique. The results suggested that GC induced rapid inhibitory effects on I_(ACh) in PC12 cells are probably mediated by a nongenomic mechanism. The inhibitory effect of various GC on I_(ACh) are different.

Key words: Glucocorticoids;Nicotinic ACh receptor;Phaeochromocytoma cells;Nongenomic

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Citing This Article：

Shi Lijun, Wang Chunan, Chen Yizhang. RAPID inhibitory effect of glucocorticoids on ACh-induced current in rat phaeochromocytoma cells. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).