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Effect of hypoxia on angiotensin-converting enzyme activity and gene expression of intrapulmonary artery smooth muscle cells

Yu Tianzheng, Ma Chuantao

Laboratory of Cardiovascular Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

In order to observe the effect of hypoxia on pulmonary artery smooth muscle cells (PASMC), angiotensin-converting enzyme (ACE) activity was measured by colometry and the expression of ACE mRNA was detected by Northern blot, using rabbit isolated and cultured PASMC. The results suggest that PASMC ACE increased by hypoxia might play an important role in the development of hypoxic pulmonary hypertension.

Key words: Hypoxia;Pulmonary artery;Vascular smooth muscle cell;Angiotension converting enzyme (ACE);Rabbit

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Citing This Article：

Yu Tianzheng, Ma Chuantao. Effect of hypoxia on angiotensin-converting enzyme activity and gene expression of intrapulmonary artery smooth muscle cells. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).