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Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei；China

Abstract

Thirty-two rabbits were used to investigate the effect of nitric oxide (NO) on the myoelectric activity of the sphincter of Oddi (SO) and arterial blood pressure. Intravenous infusion of N~(G)-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthase (NOS), caused increased in SO phasic wave amplitude and arterial blood pressure. The increase in SO phasic wave amplitude by infusion of L-NNA was reversed by L-arginine, but arterial blood pressure remained at a high level. It was observed that SO phasic wave amplitude, frequency and arterial blood pressure were significantly decrease by intravenously infusion of sodium nitroprusside (SNP), a substance producing.

Key words: Sphincter of Oddi;Myoelectric activity;Nitric oxide;Arterial blood pressure;Rabbit

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Citing This Article：

Zhang Min, Ding Chunhua, Zhang Lianwei, Yang Siyu. Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).