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Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia

Ma Bei, Yi Bida, Xing Baoren

Department of Physiology,Second Military Medical University.Shanghai 200433；China

Abstract

In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione.

Key words: Glucocorticoid;Paravertebral ganglia;Excitatory postsynaptic potential;Rapid effect

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Citing This Article：

Ma Bei, Yi Bida, Xing Baoren. Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).