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Changes in the binding characteristics of central #kappa#-opioid receptor during the development of 100Hz electroacupuncture (EA) tolerance in rats

Dong Yina, Mao Muhua, Mao Xiaomin, Han Jisheng

Neuroscience Research Institute,Beijing Medical University.Beijing 100083；China

Abstract

The effect of repetitive 100Hz EA stimulation on the characteristics of binding of #kappa# opioid receptors in discrete brain regions and the spinal cord of rats was investigated by radioligand binding assay. 100Hz EA was administered once a day (30min) for 7d. Changes in B_(max) and Kd of #kappa# opioid receptors of 4 discrete brain regions (cortex, midbrain, pons-medulla and striatum) and spinal cord were observed at d 1, 3, 5 and 7, respectively.

Key words: Electroacupuncture;Analgesia;Tolerance;#kappa#-opioid receptor

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Citing This Article：

Dong Yina, Mao Muhua, Mao Xiaomin, Han Jisheng. Changes in the binding characteristics of central #kappa#-opioid receptor during the development of 100Hz electroacupuncture (EA) tolerance in rats. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).