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Enhancement of taurine-activated whole-cell currents by serotonin in rat sacral dorsal commissural neurons

Wang Dianshi, Xu Tianle, Pang Zhiping, Li Jishuo

Department of Anatomy and K.K.Leung Brain Research Centre,Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Using nystatin-perforated whole-cell recording configuration, the modulatory effect of serotonin (5-hydroxytryptamine, 5-HT) on taurine (Tau)-activated current (I_(Tau)) was investigated in neurons dissociated from the rat sacral dorsal commissural nucleus (SDCN). In accordance with our previous study, it is suggested that 5-HT may play an important antinociceptive function in SDCN through enhanced Gly and Tau inhibitory effects.

Key words: 5-hybroxytryptamine;Taurine;Perforated whole-cell recording;Sacral dorsal commissural nucleus

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Citing This Article：

Wang Dianshi, Xu Tianle, Pang Zhiping, Li Jishuo. Enhancement of taurine-activated whole-cell currents by serotonin in rat sacral dorsal commissural neurons. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).