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Zn~(2+) depresses GABA_(A) receptor mediated responses in acutely dissociated sacral dorsal commissural neurons

Pang Zhiping, Wang Dianshi, Xu Tianle, Li Jishuo

Department of Anatomy and K.K.Leung Brain Research Centre,Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

The effects of Zn~(2+) on GABA_(A)-receptor mediated responses in acutely isolated rat sacral dorsal commissural nucleus (SDCN) were studied using nystatin-perforated whole cell recording techniques. The results demonstrated that GABA induced inward currents through activation of GABA_(A)-receptor at a holding potential of -40mV; GABA_(A)-receptor mediated responses were suppressed by Zn~(2+) in a reversible and voltage-independent manner; and in the presence of Zn~(2+), the concentration-response curve of GABA-induced responses was shifted to the right in a parallel manner.

Key words: Zinc;GABA_(A)-receptor;Nystatin-perforated whole cell recording;Dissociated cells;Sacral dorsal commissura nucleus

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Citing This Article：

Pang Zhiping, Wang Dianshi, Xu Tianle, Li Jishuo. Zn~(2+) depresses GABA_(A) receptor mediated responses in acutely dissociated sacral dorsal commissural neurons. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).