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Effect of intracarotid injection of adenosine on the activity of RVLM neurons in barodenervated rats

Chen Shuang, He Ruirong

Department of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

To observe the effect of intracarotid administration of adenosine of adenosine on neurons in the rostral ventrolateral medulla (RVLM) region, 72 spontaneous active units were extracellularly recorded from 28 Sprague-Dawley rats with sino-aortic denervation. Results indicate that Ado can induce an inhibition of spontaneous electrical activity of RVLM neurons, an effect which is mediated by adenosine A_(1)-receptor with the involvement of ATP-sensitive potassium channels.

Key words: Adenosine;Rostral ventrolateral medulla;Spontaneous single-unit discharge;8-phenyltheophylline;8-cyclopentyl-1, 3-dipropylxanthine;Glibenclamide

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Citing This Article：

Chen Shuang, He Ruirong. Effect of intracarotid injection of adenosine on the activity of RVLM neurons in barodenervated rats. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).