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Effects of morphine on the formalin induced IL-2R #beta# mRNA expression of rat hippocampus

Wu Xuan, Li Haidi, Li Xicheng, Ruan Huaizhen, Wang Jian

Department of Physiology,The Third Military Medical University.Chongqing 400038

Abstract

Using mothod of in situ hybridization, the effects of subcutaneous injection (sc) of formalin (For) into one hindpaw (hyperalgesia) on IL-2R #beta# mRNA expression in hippocampus (Hip) were studied. In addition, the effects of coadministration of morphine (ip) or ACTH (ip) with For (sc) were studied also. The results suggest that IL-2R might be involved in pain modulation.

Key words: Interleukin-2R#beta#mRNA;Hippocampus;Morphin;ACTH;In situ hybridization

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Citing This Article：

Wu Xuan, Li Haidi, Li Xicheng, Ruan Huaizhen, Wang Jian. Effects of morphine on the formalin induced IL-2R #beta# mRNA expression of rat hippocampus. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).