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Alterations of cardiac G_(i) protein alpha subunits during ischemia-reperfusion in rats

Wang Yao, Wu Liling, Ge Mingzhu

Department of Pathophysiology,Beijing Medical University.Beijing 100083

Abstract

Alteration of G proteins in rat heart during ischemia-reperfusion was studied. Levels of G_(i#alpha#2), G_(i#alpha#3) and G_(s#alpha#) in sarcolemma and light vesicle were measured by Western blot analysis. Adenyl cyclase activities were determined by radioimmunoassay. The results suggested that the increased expression of cardiac G_(i) may contribute to the dysfunction of adenyl cyclase signal transduction system and the impaired cardiac function during ischemia-reperfusion.

Key words: G protein;Ischemia-reperfusion;Signal transduction;Adenyl cyclase

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Citing This Article：

Wang Yao, Wu Liling, Ge Mingzhu. Alterations of cardiac G_(i) protein alpha subunits during ischemia-reperfusion in rats. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).