Issue Archive

Effects of 17#beta#-estradiol on delayed rectifier potassium channels in hippocampal pyramidal neurons of the rat

Abstract

After application of 1.0 and 10.0nmol/L E2, the open probabilities of K~(+) channels were decreased from (67.4±18.2)% to (41.2±12.5)% and from (56.3±15.8)% to (13.2±12.6)% respectively, the open frequencies were reduced from (43.40±6.7)Hz to (27.68±9.1)Hz and from (38.19±10.1)Hz to (15.79±3.5)Hz respectively. Meanwhile, there was a shortening of the mean open time and a lengthtening of the mean close time of the channels.

Key words: 17#beta#-estradiol;Potassium channel;Hippocampal neuron;Patch-clamp

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

. Effects of 17#beta#-estradiol on delayed rectifier potassium channels in hippocampal pyramidal neurons of the rat. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).