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Effect of nitric oxide release on epileptiform discharge in CA1 area of hippocampal slices

Abstract

The linear relationship range and detection limit of SNM were 4.5×10~(-4)-1.0×10~(-8)mol/L and 5.0×10~(-8)mol/L respectively. Penicillin (PEN) could elevate NO release, the number and amplitude of stimulus-evoked field potentials spike (SEPS) in concentration-dependent manner; Both 7-NI and L-NNA depressed NO release and partly reversed and effect of penicillin.

Key words: Penicillin-induced seizure in hippocamal slice;Nitric chide NO-sensitive microelectrode;7-nitro-indazole;N~(#omega#)-nitro-L-arginine;

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Citing This Article：

. Effect of nitric oxide release on epileptiform discharge in CA1 area of hippocampal slices. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).