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The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs

Abstract

It has been previously shown that the activation of A_(1) adenosine receptors in frogmelanotroph induced a hyperpolarization accompanied by blockage of spontaneous action potentials. In the present report, we explored mechanisms underlying the above phenomenon using the pacth-clamp technique in whole-cell and cell-attached configuration. The result showed that adenosine could increase the opening of non-voltage-activated potassium channels leading to hyperpolarization, but an inward cation current activated by hyperpolarizing pulse was not involved.

Key words: Melanotroph;Patch-clamp technique;Potassium channel;I_(h)

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Citing This Article：

. The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).