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Studies on the mechanism of #alpha#-MSH in reducing IL-1#beta#-induced fever

Abstract

#alpha#-MSH markedly suppressed febrile response (P<0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1#beta# (P<0.01). The cAMP content of the medium in which the hypothalamic was incubated for 40 min in the presence of IL-1#beta# was significantly increased (P<0.01). However, this increase action could be prevented by a pretreatment with #alpha#-MSH.

Key words: Melanocyte-stimulating hotmone;Interleukin-1;Adenosine cyclic;Hypothalamus; Fever

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Citing This Article：

. Studies on the mechanism of #alpha#-MSH in reducing IL-1#beta#-induced fever. Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).