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Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro

Abstract

The results showed that the potentiation of acetylcholine (ACh) on both the burst of spike and the contractility were inhibited by morphine, which could be completely antagonized by CCK-8. The CCK-8 effect, again, could be suppressed by CCK-A receptor antagonist devazepide (10mol/L), but partially by CCK-8 receptor antagonist L-365, 260 at 10nmol/L or completely at concentration of 30nmol.L.

Key words: Cholecystokinin octapeptide;Cholecystokinin receptor;Antagonist jejunum; Electrical activity;Contraction;

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Citing This Article：

. Antagonistic effect of CCK-8 on morphine-inhibited electrical and contractile activities of rat jejunum in vitro. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).