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Angiotensin II type 2 receptor gene deletion does not affect renin-angiotensin system

Abstract

It was shown that the concentrations of Angiotensin II in plasma and kidney tissues and the expressions of renin and AT1A receptor in the AT2 gene null mice were unchanged, as compared with those in AT2 wild-type mice. This result suggests that gene deletion of AT2 receptor does not markedly impact the stability of renin-angiotensin system and the inductive function of AT2 receptor is compensated in a way remaining to be clarified.

Key words: AT2 receptor;Gene deletion;Renin-angiotensin system

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Citing This Article：

. Angiotensin II type 2 receptor gene deletion does not affect renin-angiotensin system. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).