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Effects of Cs on automaticity and pacemaker current I_(f) and I_(K) in rabbit sinus node cells

Abstract

Conventional microelectrode and perforated patch clamp techniques were employed to study the pacemaker mechanisms in enzyme-isolated rabbit sinus node cells. 2 mmol/L Cs had little effect on automatic discharge of the SA node and the slope of diastolic depolarization. Cs blocked both I_(f) and slope conductance increase but left I_(k) largely unaffected. The results suggest that I_(f) is not essential for the first stage of automatic activity of the rabbit SA node.

Key words: Sinus node;Patch clamp;Pacemaker cruuent;Action potential

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Citing This Article：

. Effects of Cs on automaticity and pacemaker current I_(f) and I_(K) in rabbit sinus node cells. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).