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Pathways of signal transduction of intracellular Ca~(2+) increase mediated by three subtypes of #alpha#_(1)-adrenoceptor in HEK293 cells

Abstract

In HEK293 cell lines in which #alpha#_(1a)-, #alpha#_(1b)- or #alpha#_(1d)-adrenoceptor subtypes were stably expressed, fluorescence intensities due to traces of Ca~(2+) were investigated using fura-2/AM with the aim of exploring signal transduction pathways of intracellular Ca~(2+) increase mediated by these receptor subtypes.

Key words: #alpha#_(1)-adrenoceptors;Receptor subtype;G protein;Phospholipase C;Protein kinase C;Cyclic AMP;Tyrosine kinase;Fura-2

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Citing This Article：

. Pathways of signal transduction of intracellular Ca~(2+) increase mediated by three subtypes of #alpha#_(1)-adrenoceptor in HEK293 cells. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).