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GABA initiates the acrosome reaction and fertilizing ability in human sperm

Abstract

Results indicate that GABA may be involved in the modulation of the AR and the fertilization process in capacitated human spermatozoa through a calcium mediated mechanism, thus opening up posibilities for studies of signal transductions through activation of the GABA_(A) receptor present on the sperm surface.

Key words: GABA;Progesterone;Sperm;Acrosome reaction;Sperm penetration assay (SPA) [Ca~(2+)]_(i) assay;

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Citing This Article：

. GABA initiates the acrosome reaction and fertilizing ability in human sperm. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).