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Modulation of endothelin-1 on pulmonary surfactant secretion

Abstract

The effects of endothelin-1 (ET-1) at physiological level on the secretion of pulmonary surfactant (PS) were studied on isolated nonperfused rat lungs. Results suggest that ET-1 at the physiological concentration is involved in modulating PS secretion through a PKC-dependent pathway, and can also promote ET production in lungs.

Key words: Endothelin-1;Pulmonary surfactant;Protein kinase C;Isolated nonperfused lung

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Citing This Article：

. Modulation of endothelin-1 on pulmonary surfactant secretion. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).