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The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy

Abstract

The time course of alteration in neuronal nitric oxide synthase (nNOS) and the influence of glutamate receptor antagonists on immunoreactivity of nNOS were investigated immunohistochemically in rat hippocampus during penicillin-induced epilepsy. These results suggest that the increase of nitric oxide may be related to the injury of neurons during and aft er epilepsy; the changes of nNOS may be related to the activity of NMDA and non-NMDA receptors. Neuron protective effect of MK-801 and DNQX may be in part mediated by nNOS.

Key words: Epilepsy;Hippcampus;Neural nitric oxide synthase;DNQX;MK-801

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Citing This Article：

. The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).