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Neurokinin-1 receptor mediated formalin-induced c-fos expression in the rat spinal cord

Abstract

In the present work, the effects of tachykinin receptor antagonists on formalin-induced c-fos expression in the rat spinal cord were studied by a combination of immunocytochemical and neuropharmacological methods. Results indicated that NK-1 receptor mediated formalin-induced c-fos expression in the spinal cord, suggesting NK-1 receptor might play an important role in the spinal transmission of nociceptive messages.

Key words: Substance P;Pain;c-fos;Spinal cord

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Citing This Article：

. Neurokinin-1 receptor mediated formalin-induced c-fos expression in the rat spinal cord. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).