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L-phenylalanine and smooth muscle cell proliferation from SHR and WKY rats

Abstract

Cell growth and proliferation were evaluated in cultured vascular smooth muscle cells (VSMCs) isolated from spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) rat aortae by measuring [~(3)]-thymidine incorporation into newly synthesized DNA and by determining cell number, respectively. The resutls showed that L-phenylalanine could exert a direct and specific antiproliferative effect on VSMCs suggesting that such effect can account for the antihypertensive action of this amino acid observed in SHR.

Key words: L-phenylalanine;Vascular smooth muscle cells;Cell growth

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Citing This Article：

. L-phenylalanine and smooth muscle cell proliferation from SHR and WKY rats. Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).