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Peripheral substance P receptor mediating c-fos gene expression in the spinal dorsal horn induced by peripheral noxious stimulation

Abstract

Employing immunohistochemical staining for FOS protein, which is the expression product of c-fos proto-oncogene, the role of substance P receptor (SPR) in noxious information transmission at peripheral terminals of the dorsal root ganglion cells was investigated by means of a selective SPR antagonist L668, 169 and agonist Sar-SP. These results indicated the SP might contribute to the transmission of nociceptive information and induce noxious sensation, at least in part by activating SPR in peripheral terminals of the dorsal root ganglion cells.

Key words: Substance P;Substance P receptor;c-fos;Dosal horn of the spinal cord;Noxious stimulation;Rat

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Citing This Article：

. Peripheral substance P receptor mediating c-fos gene expression in the spinal dorsal horn induced by peripheral noxious stimulation. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).