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Protective effect of interleukin-1#beta# on acetaminophen induced liver damage in mice

Sun Hong, Li Jiyao, Yu Jiren

Department of Physiology, Beijing Medical University. Beijing 100083

Abstract

Treatment with IL-1#beta# of different doses (10 000, 30 000 or 50 000 U/kg) 12 h before the administration of acetaminophen could reduce the leakages of transaminases in a dose dependent manner and decrease the mortality of mice. The protective effect of IL-1#beta# on the liver could be abolished by IL-1#beta# receptor antagonist. Further experiments showed that IL-1#beta# could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen. IL-1#beta# could also reduce malondiadehyde (MDA) content enhanced by acetaminophen.

Key words: Interleukin-1#beta#;Acetaminophen;Hepatoprotection

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Citing This Article：

Sun Hong, Li Jiyao, Yu Jiren. Protective effect of interleukin-1#beta# on acetaminophen induced liver damage in mice. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).