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Modulation mechanism of IL-1 in hemorrhagic shock in relation to endotoxin

Shi Hanping, Miao Mingyong, Qin Luping, Gao Han, Xu Renbao

Departmant of General Surgery, The South Hospital, First Military Medical University. Guangzhou 510515, Guangdong

Abstract

The modulation mechanism of IL-1 in relation to endotoxin (ET) was investigated in hemorrhagic shock rat. It was found that within 4 h after hemorrhagic shock, SD rat showed a significant increase in both ET and IL-1, the latter taking place earlier than the former. While SD rat reared in germ free condition showed an obvious increas in IL-1 but without marked change in ET, no matter whether the rats reared in different condition were pretreated with lactulose or anti-ET. Within 5 d after reinfusion of lost blood to teh ordinary shock rat, IL-1 and ET changed in a parallel manner. When shock rats were treated with lactulose or anti-ET, both IL-1 and ET showed significant decrease as compared with the control. It is suggested from the above observation that ET is not an important factor in enhancing IL-1 activity in the later phase of hemorrhagic shock. The ET comes mainly from the gut in hemorrhagic state.

Key words: Hemorrhagic shock;Endotoxin;Interleukin-1

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Citing This Article：

Shi Hanping, Miao Mingyong, Qin Luping, Gao Han, Xu Renbao. Modulation mechanism of IL-1 in hemorrhagic shock in relation to endotoxin. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).