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Changes of CGRP levels in plasma and CGRP mRNA in dorsal root ganglia during endotoxicosis in the rat

Tang Yueming, Han Qide, Xing Yutong, Bai Yan, Wang Xian

Institute of Vascular Medicine, The Third Hospital, Beijing Medical University. Beijing 100083

Abstract

The results showed that plasma CGRP, but not mRNA, began to increase 30 min after endotoxin (5 mg/kg, i.v.) administration. On the other hand, the CGRP levels in plasma and CGRP mRNA in DRG were significantly increased by 142% and 32% respectively at the 3 h of injection and by 216% and 85% respectively at the 8 h of injection.

Key words: Endotoxicosis;Dorsal root ganglia;Calcitonin gene-related peptide;mRNA

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Citing This Article：

Tang Yueming, Han Qide, Xing Yutong, Bai Yan, Wang Xian. Changes of CGRP levels in plasma and CGRP mRNA in dorsal root ganglia during endotoxicosis in the rat. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).