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Effect of microinjection of adrenaline (E) into the rostral ventrolateral medulla on the parameters of the hemorrheology

Wang Shihong, Guo Xueqin

Department of Physiology, Shanghai Medical University. Shanghai 200032

Abstract

Experiments were performed on SD rats. It was found that hyperviscosity could be induced by restrained conscious rats. Microinjection of adrenaline (E) into the rostral ventrolateral medulla (rVLM) resulted in a facilitatory increase in blood viscosity, which was blocked by bilateral microinjection of #alpha#-adrenoceptor antagonist (phentola mine) into the same area, but not by #beta#-adrenocetor antagonist (propranolol). Pretreatment of rVLM area with 6-hydroxydopamine (6-OHDA) or microinjection of phentolamine abolished stress-induced hyperviscosity, while propranolol was without effect. Apparently the E caused increase of the blood viscosity or stress-induced hyperviscosity may be mediated by activation of #alpha#-adrenoceptor in the rVLM.

Key words: Adrenaline;Rostral ventrolateral medulla;Stress;Hyperviscosity

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Citing This Article：

Wang Shihong, Guo Xueqin. Effect of microinjection of adrenaline (E) into the rostral ventrolateral medulla on the parameters of the hemorrheology. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).