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Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response

Gu Yunhui, Xu Weike, Lu Yichun, Wang Yiguang, Tan Lu

Department of Physiology, Beijing Medical University. Beijing 100083

Abstract

In urethane-anesthetized, tubocurarine- immobilized and artificially ventilated rats, glutamate (Glu) injection into the insular cortex (INS) and substance P injection into the lateral hypothalamus-perifornical region (LH/PF) or nucleus paraventricularis (NPV) caused pressor responses. Preinjection of procaine or glutamate diethyl ester (GDEE, a glutamate antagonist) bilaterally into the nucleus amygdaloideus centralis (AC) and [D-Pro~(2), D-Phe~(7), D-Trp~(9)] -substance P (DPDPDT, a substance P antagonist), but not GDEE, into the LH/PF markedly attenuated the pressor response induced by glutamate injection into the INS. Procaine or DPDPDT preinjection into the NPV also reduced the INS-pressor response.

Key words: Insular cortex;Amygdaloideus centralis;Lateral hypothalamus;Nucleus paraventricularis;Substance P antagonist

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Citing This Article：

Gu Yunhui, Xu Weike, Lu Yichun, Wang Yiguang, Tan Lu. Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).