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Inhibition of transient outward potassium current in rat ventricular myocytes by propofol

Zhou Jun, Tian Ming, Zhou Zhaonian

Shanghai Institute of Physiology, Chinese Academy of Sciences.Shanghai 200031；China

Abstract

Whole-cell patch-clamp technique was applied to investigate the effect of propofol (25,50 #mu#mol/L) on transient outward potassium current (I_(to)) in rat ventricular myocytes. It was shown that the amplitude of I_(to) was decreased significantly after exposure to propofol. The effect is partially reversible after washing. At applied potential≥0 mV, statistical significant differences reached between propofol(25 and 50 #mu#mol/L) group and the control group could be found. The voltage-dependent manner and the outward rectifier character were not affected by the drug at the two concentrations.

Key words: Propofol;Whole-cell patch-clamp technique;Transient outward potassium current

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Citing This Article：

Zhou Jun, Tian Ming, Zhou Zhaonian. Inhibition of transient outward potassium current in rat ventricular myocytes by propofol. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).