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Inhibition of voltage-dependent K~(+) currents in rat C_(6) glioma cells by haloperidol and R(-)-NPA

Xie Zhong, He Shufang

Shanghai Brain Research Institute, Chinese Academy of Sciences. Shanghai 200031

Abstract

In this study, the inhibitory effects of R (-) -NPA (R (-) - Propylnorapomorphine) and haloperidol on voltage-dependent K~(+) currents in rat C_(6) glioma cells (C_(6) cells) were observed by means of the whole-cell patch-clamp recording technique. The mechanisms of the effects were also analyzed.The main results were as follows:(1) Both R (-) -NPA and haloperidol could inhibit K~(+) currents dose-dependently and reversibly in C_(6) cells. (2) R (-) -NPA and haloperidol inhibited mainly the slow component of the K~(+) currents. (3)These inhibitory responses were not mediated by dopamine receptors or dependent on G-proteins and intracellular calcium. It was suggested that they refer to some direct action on K~(+) channels.

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Citing This Article：

Xie Zhong, He Shufang. Inhibition of voltage-dependent K~(+) currents in rat C_(6) glioma cells by haloperidol and R(-)-NPA. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).