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Somatostatin inhibited pain modulation action of substance P in spinal cord

Ruan Huaizhen, Li Xicheng, Cai Wenqin

Department of Physiology,Third Military Medical College.Chongqing 630038；China

Abstract

In the present study, the effect of somatostatin (SST) on pain modulation induced by substance P in spinal cord was studied. The results showed that intrthecal injection of SST increases pain threshold, prevented pain response and c-fos expression in spinal cord induced by SP.Injection of formalin in the hindpaw induced pain response and increased the SP-LI,which could be inhibited by injection of SSt. It is suggested that the analgesic effect of SST may be resulted from the inhibition of the noxious response induced by SP.

Key words: Substance P;Somatostatin;Proto-oncogene c-fos;Fos protein;Spinal cord;Immunohistochemistry

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Citing This Article：

Ruan Huaizhen, Li Xicheng, Cai Wenqin. Somatostatin inhibited pain modulation action of substance P in spinal cord. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).