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Effect of microinjection of CRH into rat central nucleus of amygdala on blood pressure and its central mechanism

Guo Juan, Yin Weiping, Huang Weiqiu, Xu Bin, Qian Zhongming

Department of Physiology, Suzhou Medical College.Suzhou 215007,Jiangsu；China

Abstract

(1)Microinjection of Corticotropin releasing hormone(CRH)100,500 ng into the tral nucleus of amygdala(CeA) produced a dose-dependent increase in blood pressure. The response occurred 5 min after injection and lasted for at least 1 h .(2) The response could be blocked by injection of CRH receptor antagonist #alpha#-helical CRH_(9-41) into CeA. (3) Lateral ventricle injection of naloxone could also attenuate the pressor response of CRH. (4) After injection of #alpha#-helical CRH_(9-41) into nucleus of soltary tract, the pressor response of CRH was diminished.

Key words: Central nucleus of amygdala;Corticotropin releasing hormone (CRH）;CRH receptor;Antagonist;Naloxone nucleus of solitary tract;Blood pressure

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Citing This Article：

Guo Juan, Yin Weiping, Huang Weiqiu, Xu Bin, Qian Zhongming. Effect of microinjection of CRH into rat central nucleus of amygdala on blood pressure and its central mechanism. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).