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Effects of intraventricular injection of adenosine on renal sympathetic nerve activity

Ma Xiuying, Sun Guangqi, He Ruirong

Department of Physiology, Institute of Basic Medicine,Hebei Medical Colloge.Shijiazhuang 050017,Hebei

Abstract

The effects of intraventricular injection of adenosine and its analogues on renal sympathetic nerve activity (RSNA) were examined in sinoaortic denervated and vagotomized anesthetized rats. In response to intraventricular bolus injection of adenosine,RSNA was increased by 41.9±6.08%(P＜0.001),mean arterial pressure (MAP) was initially increased by 1.39±0.19 kPa (P＜0.001) and subsequently decreased by 3.74±0.64 kPa (P＜0.001), and heart rate (HR) was reduced by 95±14 bpm (P＜0.001). To determine the adenosine-receptor subtype which mediates the response of RSNA to adenosine, we used selective A_(1)-receptoragonist (R-PIA) and A_(2)-receptor agonist (NECA) and found that MAP and HR were reduced by R-PIA and NECA. The effects lasted significantly longer than those of adenosine. R-PIA induced an increased in RSNA by 31.6±5.21%(P＜0.001), while NECA showed no effect on RSNA. The renal sympathoexcitatory response to intraventricular injection of adenosine was completely inhibited by pretreatment with a selective A_(1)-receptor antagonist (DPCPX). Following the bilateral stellate ganglionectomy, intraventricular injection of adenosine failed to induce the increase in RSNA. The results indicate that adenosine may activate cardiac sympathetic afferents through A_(1)-receptor, resulting in a reflex augmentation of RSNA.

Key words: Adenosine;Adenosine analogues;Adenosine receptors;Renal sympathetic nerve activity;Cardiac sympethetic afferents

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Citing This Article：

Ma Xiuying, Sun Guangqi, He Ruirong. Effects of intraventricular injection of adenosine on renal sympathetic nerve activity. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).