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Expression of c-fos mRNA induced by pressure overload in the left ventricle

Tan Dingding, Zhong Chunning, Chen Weihong, Pan Jingyun, Hu Benrong

Laboratory of Molecular Biology, Sun Yat-Sen University of Medical Sciences. Guangzhou 510089, Guangdong； China

Abstract

In the present study the effect of pressure overload on the expression of protooncogene c-fos in the left ventricle was investigated in rats with abdominal aorta constriction. It was found that a remarkable expression of c-fos was induced by pressure overload and the expression was greatly attenuated by angiotensin converting enzyme inhibitor captopril. In the pressure overload group the angiotensinogen mRNA level was found increased. The above results suggest that angiotensin II is involved in the expression of c-fos due to pressure overload.

Key words: Pressure overload;c-fos;Captopril;Angiotensinogen

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Citing This Article：

Tan Dingding, Zhong Chunning, Chen Weihong, Pan Jingyun, Hu Benrong. Expression of c-fos mRNA induced by pressure overload in the left ventricle. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).