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Effect of neuromedin C on gastrin secretion from isolated and perfused rat stomach

Li Yongyu

Department of Pathophysiology, Zunyi Medical College. Zunyi 563003, Guizhou

Abstract

Using a model of isolated and perfused rat stomach, it was observed that the gastrin secretion was increased significantly by intravascular perfusion of 10~(-8) mol/L neuromedin C (NMC)(from 550±126 pg/10 min to 1060±180 pg/10 min, P<0.01). The effect was in part suppressed by atropine (10~(-7mol/L)(756±152 pg/10 min v.s.1060±180 pg/10 min, P<0.05) and completely blocked by D-Phe~(6)-BN(6-13) OMe(10~(-6)mol/L), a bombesin receptor antagonist from human antral G-cells.

Key words: Perfused rat stomach;Bombesin antogonist;Neuromedin C;Gastrin secretion;Cholinergic pathway

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Citing This Article：

Li Yongyu. Effect of neuromedin C on gastrin secretion from isolated and perfused rat stomach. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).