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Effects of oxygen free radicals on myocardial #alpha#_(1)-adrenoceptor and its subtypes in rat

Gong Haibin, Han Qide

Institute of Vascular Medicine, The Third Hospital, Beijing Medical University. Beijing 100083

Abstract

The effects of oxygen free radicals on myocardial #alpha#_(1)-adrenoceptor and its subtypes and #beta#-adrenoceptor were observed by the method of radioligand binding assay in rat. The experiments showed: (1)·OH and O~(.)_(2) reduced the B_(max) of #alpha#_(1)-adrenoceptors binding to~(125)IBE2254 by 55% and 36%, respectively. (2) The K_(1) values of #alpha#_(1)-adrenoceptors were increased by ·OH(by 171%), but not by O~(.)_(2) increased the ratio of #alpha#_(1A) vs #alpha#_(1B) subtypes. (4)#beta#-adrenoceptors were not changed by either ·OH or O~(.)_(2). (5)Oxygen free radical scavengers mannitol and superoxide dismutase were capable of preventing the changes of #alpha#_(1)-adrenoceptor and its subtypes induced by oxygen free radicals.

Key words: Free radicals;Heart;;

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Citing This Article：

Gong Haibin, Han Qide. Effects of oxygen free radicals on myocardial #alpha#_(1)-adrenoceptor and its subtypes in rat. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).