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Correlation between ability of learning-memory and synaptosomal free [Ca~(2+)]_(i) in mice of different age

Du Hongyan, Zhang Weining, Zhang Zigui, Shao Yue, Wang Liangbin, Wang Jinxi, Wu Fumei

Department of Biological Science and Technology, Nanjing University. Nanjing 210093, Jiangsu； China

Abstract

In the present investigation, the behavior of learning and memory of 1-month and 6-month-old mice was studied by using Y-maze and one-trial passive avoidance response device. The synaptosomal free [Ca~(2+)]_(i) of four main brain regions (Hippocampus, Cerebral cortex, Cerebellum, Tectum of midbrain)of these mice were measured by fluorescent probe Ca~(2+) indicator Fura-2 and an AR-CM-MIC cation measurement system. The results showed that, in comparison with 1-month-old mice, the ability of discrimination learning and memory of 6-month-old ones were attenuated, and the synaptosomal free [Ca~(2+)]_(i) of hippocampus was increased.

Key words: Mice;Learning and memory;Brain synaptosome;[Ca￣（2+）]_(i)

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Citing This Article：

Du Hongyan, Zhang Weining, Zhang Zigui, Shao Yue, Wang Liangbin, Wang Jinxi, Wu Fumei. Correlation between ability of learning-memory and synaptosomal free [Ca~(2+)]_(i) in mice of different age. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).