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Subtypes of glutamate receptor and their distribution in the somatic membrane of neurons freshly isolated from rat DRG

Si Junqiang, Li Zhiwang, Fan Youzhen

Research Center of Experimental Medicine, Tongji Medical University. Wuhan 430030, Hubei

Abstract

The aim of the present study was to investigate the distribution and coexistance of glutamate(Glu)receptor subtypes in the isolated rat DRG neurons as identified by the recorded NMDA-, KA- or QA/AMPA- activated current using whole-cell patch-clamp technique. Of the 37 identified neurons, 15 contain only a single subtype receptor, 13 with two kind subtype receptors, only 4 with all subtype receptors. With regard the frequency of occurrance of the three types of receptors, the NMDA, KA and QA/AMPA subtype were found present respectively in 26(70.3%), 7(18.9%)and 21(56.8%) of the recorded cells.

Key words: Rat;;;Whole-cen patch-clamp techniques;NMDA receptor;Kainatereceptor;Quisqualate receptor

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Citing This Article：

Si Junqiang, Li Zhiwang, Fan Youzhen. Subtypes of glutamate receptor and their distribution in the somatic membrane of neurons freshly isolated from rat DRG. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).