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Hypoxia induced increase of MDA and echinocytes from erythrocytes in rabbit^s blood with special reference to inhibition of the increase by MPEG-SOD

Han Zhanyuan, Chen Ming, Lu Jiren, Wen Ping, Song Xuelei, Wu Qiying

Shanghai Institute of Physiology, Chinese Academy of Sciences. Shanghai 200031； China；Department of Biology, Fudan University. Shanghai

Abstract

When rabbits acutely exposed to hypobaric hypoxia MDA (malondialdehyde) in erythrocyte and plasma increased significantly during hypoxia periods of 1,2,3,5 and 24h. The increase of MDA in plasma could be prevented by vitamin E, but that in erythrocyte did not show significant change. The echinocytes from erythrocytes increased significantly after hypoxia for 24h (n=5, P<0.05vs. normoxia group). However, by injecting MPEG-SOD(monomethoxypolythlene glycol-SOD) intravenously 30 min before hypoxia, the increase of MDA (both of erythrocyte and plasma)and echinocytes(from erythrocytes)were both inhibited obviously during hypoxia for 24h(n=5, P<0.05, P<0.01 vs. hypoxia group).

Key words: Hypoxia;Blood;Monomethoxypolythlene glycol-SOD;Malondialdehyde;Superoxide

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Citing This Article：

Han Zhanyuan, Chen Ming, Lu Jiren, Wen Ping, Song Xuelei, Wu Qiying. Hypoxia induced increase of MDA and echinocytes from erythrocytes in rabbit^s blood with special reference to inhibition of the increase by MPEG-SOD. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).