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Effects of (-)SPD and (-)THP on the firing of noradrenergic neurons in locus coeruleus

Wu Jianhua, Jin Guozhang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031

Abstract

The effects of (-)SPD and (-)THP on the noradrenergic neurons in rat locus coeruleus were investigated by recording the in vivospontaneous firing . It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on #alpha#_(2) autoreceptors in a dose-dependent manner, while #alpha#_(2) receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory firing of the neurons, however, irreversible.

Key words: Locus coeruleus;Unit firing;(-)stepholidine;(-)tetrahydropalmatine

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Citing This Article：

Wu Jianhua, Jin Guozhang. Effects of (-)SPD and (-)THP on the firing of noradrenergic neurons in locus coeruleus. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).