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Excitation of hypothalamic nucleus arcuatus neuron induced decrease of plasma sialic acid level in rats

Chen Wenfang, Chen Jiajin, Chen Lei

Department of Physiology, Qingdao Medical College. Qingdao 266021, Shandong

Abstract

The plasma SA level was significantly decreased after microinjection of Glu into the ARC (P<0.01). With increasing Glu concentration, the onset of the decrease occurred earlier. When Glu was microinjected into ARC after intraventricular injection of apomorphine, the plasma SA level was significantly decreased(P<0.01)and the time required to cause the decrease was shortened. When Glu was microinjected into ARC after intraventricular injection of spiperone, no change was found in the plasma SA level (P>0.05). It suggest that the mechanism underlying the decrease of plasma SA level is probably related to modulated dopamine (DA)release of hypothalamic dopaminergic neurons by DA-D2 receptor.

Key words: Sodium glutamate;Hypothalamus;Nucleus arcuatus;Plasma;Static acid;Rat

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Citing This Article：

Chen Wenfang, Chen Jiajin, Chen Lei. Excitation of hypothalamic nucleus arcuatus neuron induced decrease of plasma sialic acid level in rats. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).