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Effects of some physical and chemical factors on CGRP release from mesenteric arterial bed

Wu Zhongxin, Han Qide, Bai Yan, Wang Xian

Third Hospital, Beijing Medical University. Beijing 100083

Abstract

It was observed that low pH, elevated levels of lactic acid, hypertonic NaCl and hypertonic sucrose caused CGRP release from isolated mesenteric arterial bed (MAB) of rat. All the responses were blocked when MAB was pretreated with capsaicin. Ruthenium red, an inhibitor of Ca~(2+)-induced Ca~(2+) release from intracellular Ca~(2+) pools, significantly inhibited the release of CGRP. In Ca~(2+)free medium, low pH, lactic acid and hypertonic solutions became no longer capable of inducing the release of CGRP. It suggest that the observed release of CGRP in MAB was mediated by capsaicin-sensitive sensory nerve endings, as a result of Ca~(2+)-induced Ca~(2+) release from the intracellular Ca~(2+) store which is sensitive to ruthenium red.

Key words: Calcitonin gene-related peptide;Capsaicin;Mesenteric arterial bed

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Citing This Article：

Wu Zhongxin, Han Qide, Bai Yan, Wang Xian. Effects of some physical and chemical factors on CGRP release from mesenteric arterial bed. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).