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The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure

Gao Xi, Zhang Wanqin, Hong Janshyong

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning； USA

Abstract

Sprague-Dawley(S.D.)rats were pretreated with kainic acid(KA,10mg/kg, i.sc.)72 days before either deep prepyriform cortex(DPC)kindling or injection of the same dose of KA. The results showed that such pretreatment accelerated the process of kindling, and the KA-induced seizures appeared more severe in behaviours. c-Fos-immunoreactivity(c-Fos-ir)was used to demonstrate the neuronal activity in central nervous system during the provocative dose of KA-induced seizure, as comparing with the control which received normal saline of KA 72 days ago. The results indicated that, the tansmission pathways in two groups were just the same; but the time courses of c-fos and c-jun expression in KA pretreated group were accelerated asynchronously; and the synthesis of the proenkephalin mRNA in the Ent was apparently up-regulated.

Key words: Kainic acid;Hippocampus;c-jun;Proenkephalin mRAN;Susceptibility ;

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Citing This Article：

Gao Xi, Zhang Wanqin, Hong Janshyong. The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).