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Effect of (-) stepholidine on dopamine turnover in various brain regions

He Yufang, Huang Kaixing, Jin Guozhang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031

Abstract

(-)SPD (10mg/kg, ip) did not significantly affect the Da contents in the striatum, olfactory bulb, N. accumbens, substantia nigra, ventral tegmentum area, N. amygdala, hypothalamus, pituitary, piriform cortex, but did markedly increase the DOPAC levels in these brain areas or nuclei, and thus increase the DA turnover (DOPAC/DA). However, (-) SPD (10mg/kg, ip) did not significantly affect either the Da contents or DOPAC levels in the prefrontal cortex and cingulate cortex, thus leaving the DA turnover in these areas unchanges. These results indicated that (-) SPD did affect the nigro-striatal, midbrainlimbic and hypothalamus-pituitary DA systems, but not the midbrain-cortex DA system.

Key words: Stepholidine;Dopamine receptors;Presynaptic receptors;Dopamine turnover ;

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Citing This Article：

He Yufang, Huang Kaixing, Jin Guozhang. Effect of (-) stepholidine on dopamine turnover in various brain regions. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).