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Intracerebroventricular injection of interleukin I receptor antagonist antagonises on the generation of immuno-suppressive fator in restraint mice

Zuo Yongchang, Li Yifeng, Liu Wei, Deng Yulan, Huang Dawu, Mei Lin, Fan Shaoguang, Ding Guifeng

Department of Immunology, Beijing Medical University. Beijing 100083；China

Abstract

It was found that intracere broventricular (icv) injection of IL-1 receptor antagonist (IL-1Ra) was found capable of suppressing the production of such a serum protein under restraint stress. Nearly complete suppression could be achieved by 5.0#mu#g IL-1Ra. Intracerebroventricular injection of IL-1#beta# (1pg), however, increased the generation of the supressive protein. Neither intraperitoneal (ip) injection of Il-1Ra or IL-1#beta# had any effect on the generation of the protein. It suggest that IL-1 in brain might act as an important mediator between CNS and the immune system.

Key words: Restraint stress interleukin 1 (IL-1);Interleukin 1 receptor antagonist(IL-1Ra);Lymphocyte proliferation

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Citing This Article：

Zuo Yongchang, Li Yifeng, Liu Wei, Deng Yulan, Huang Dawu, Mei Lin, Fan Shaoguang, Ding Guifeng. Intracerebroventricular injection of interleukin I receptor antagonist antagonises on the generation of immuno-suppressive fator in restraint mice. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).